This is an often-debated question, the correct answer is, "It Depends." Is the bad guy 6 foot 2inches, 110-pound meth head wearing a t-shirt, or a 6 foot 4 inches, 360-pound offensive lineman that's just been cut form the Las Vegas raiders, wearing a leather jacket, heavy flannel shirt and long underwear in the dead of winter?
There's not a "on size fits all" situations solution. Pick a good hollow point from a reputable manufacturer that you know runs well in your gun.
The odds of needing to shoot someone in self defense are low, but never zero, the odds of your round being effective are high but never 100%.
Good hits in a high-pressure encounter is more important than having the perfect projectile for the situation.